Computer Simulation of a Mathematical Model of HAART Therapy for HIV-1 AIDS
A clinically plausible mathematical model is constructed to describe the patho-physiological dynamics of HIV-1 induced AIDS during HAART therapy. The model equations incorporate physiological interactions between non-infected helper T cells, HIV-1 infected helper T cells, HIV-1 virions in the blood plasma, HIV-1 specific cytotoxic T cells and drug molecules of the HAART protocol. Investigative computer simulations are performed to elucidate some therapeutic scenarios such as viral annihilation and efficacious HAART therapy. In particular, some mathematical criteria are derived for therapeutic outcomes such as viral persistence and viral annihilation.
HAART therapy computer simulations mathematical modeling HIV-1 dynamics AIDS cure criteria
Frank Nani Mingxian Jin
Department of Mathematics and Computer Science Fayetteville State University Fayetteville, NC 28301, USA
国际会议
上海
英文
1841-1845
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）