External Electric Field Effect on the PR Neuronal Firing under the Ephaptic Transmission
The external electric field (EF) has shown to have great influence on neurons. On account of the effects of applied fields on neural activity through the induced EF in the extracellular medium, the electrical characteristics of the extracellular medium should not be ignored for accurately reflecting the biological field effect. Here considering the electrical characteristic of extracellular medium i.e. ephaptic transmission, neuronal firing is studied based on a PR neuron model in the presence of the external (EF), including direct current (DC) and alternating current (AC) EF. Moreover, three key parameters (the inner conductance gc , the inverted potential of potassium ion VK and the extracellular resistance between dendrite and soma RDs out ), which are crucial for the dynamics of neurons, are introduced to develop the neuronal firing. Different firing rhythms of neuron imply different stimulus information, and in some particular stimulus frequency the synchronization between the firing rhythm and EF signal is observed.
external electric field PR model ephaptic transmission neuronal firing extracellular medium
Xile Wei Yinhong Chen Jiang Wang Bin Deng Meili Lu Yanqiu Che
School of Electrical Engineering and Automation Tianjin University Tianjin, China Tianjin Key Laboratory of Information Sensing & Intelligent Control, School of Automation and Electr
国际会议
上海
英文
1851-1855
2011-10-15（万方平台首次上网日期，不代表论文的发表时间）