CLINICAL AND PROGNOSTIC SIGNIFICANCE OF PREOPERATIVE SERUM CA15-3,CEA AND TPS LEVELS IN PATIENTS WITH PRIMARY BREAST CANCER
(0) Background: Serologic tumor markers such as CA15-3, CEA and TPS have been used for decades to manage patients with breast cancer. Despite the frequent use of these markers, the prognostic significance of these markers remains indeterminate. Patients and methods: We retrospectively analyzed and followed up a set of 386 patients with stage I~IV breast cancer. Serumal CA15-3 and CEA levels were measured by electrochemistry (ELC), and serumal TPS was analyzed by enzyme-linked immunosorbent assays (ELISA). We explored the relationship between preoperative serologic tumor markers and clinicopathological parameters, the correlation between CA15-3, CEA or TPS levels with overall survival, and their impact on prognosis. Results: First, at the univariate analysis, the expression of CA15-3, CEA or TPS was respectively related with some traditional prognostic factors such as age of onset, tumor size and lymph node status (P <0.05 for overall). Second, overall survival were significantly shorter among patients with elevated preoperative serum CA15-3, CEA or TPS respectively (P <0.05 for overall). Finally, multivariate Cox regression indicated that estrogen receptor(ER) expression and elevated preoperative values of CA 15-3 were independent prognostic factors for overall survival (P<0.05). Conclusions: Our study demonstrates that higher expression of preoperative serum CA15-3, CEA or TPS was closely correlated with clinicopathology and overall survival, and CA15-3 before treatment can be used as an independent prognostic parameter in patients with primarily breast cancer.
Breast cancer Prognosis CA15-3 CEA TPS
Yu-hong Zheng Yan Chen Ying-ying Lin
Laboratory of Biochemistry and Molecular Biology Research, Fujian Provincial Cancer Hospital of Fujian Medical University Teaching Hospital, Fuzhou, Fujian 350014, China
国际会议
亚太地区国际肿瘤生物学和医学学术会议、全国肿瘤标志学术大会、第六届中国中青年肿瘤专家论坛
上海
英文
163-173
2011-10-13（万方平台首次上网日期，不代表论文的发表时间）