Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified
Invasive micropapillary carcinoma (IMPC) is a rare variant of ductal carcinoma of the breast and is characterized by high metastatic potential and an aggressive clinical course. Studies of CD146 expression and function in breast cancer remain scarce. The aim of this study was to evaluate the role of CD146 and microvessel density (MVD) in breast IMPC.CD146 mRNA expression and immunohistochemistry for CD146 and MVD measured by CD31were assessed in eighty-two cases of IMPC and 137 cases of invasive ductal carcinoma, not otherwise specified (IDC-NOS). The mRNA level of CD146 in cancer specimens was higher in IMPC than IDC-NOS.CD146 expression in tumor cells was up-regulated in IMPC compared with that in IDC-NOS and was positively correlated with histological grade, ER, PR status, and P53 expression in IMPC and IDC-NOS. CD146 expression in vascular endothelial cells was significantly higher than that in IDC and was positively correlated with tumor progression in IMPC and IDC-NOS. MVD in IMPC was significantly higher than that in IDC. CD 146 expression in tumor cells was positively correlated with that in vascular endothelial cells of IMPC and IDC-NOS. The association of CD 146 expression with MVD and its correlation with progression in breast carcinoma indicated that CD146 is a potentially useful prognostic marker for breast cancer. CD146could be a new drug target in the treatment of breast cancer.
CD146 angiogenesis breast IMPC microvessel density (MVD)
Weidong Li Xiyun Yan Li Fu Dongling Yang Shuling Wang Xiaojing Guo Ronggng Lang Yu Fan Feng Gu Xinmin Zhang Yun Niu
Department of Breast Cancer Pathology and Research Laboratory of Tianjin Medical University Cancer I National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences,Beiji Department of Pathology and Laboratory Medicine, Temple University School of Medicine,Philadelphia,
国际会议
亚太地区国际肿瘤生物学和医学学术会议、全国肿瘤标志学术大会、第六届中国中青年肿瘤专家论坛
上海
英文
278-289
2011-10-13（万方平台首次上网日期，不代表论文的发表时间）