COMBINED PHENOTYPE OF FOUR MARKERS IMPROVES PROGNOSTIC VALUE OF COLON CANCER PATIENTS
Background: Combination of multiple biomarkers representing distinct aspects of tumor biology will have a better prognostic value. This study was to identify prognostic subgroups of colon adenocarcinoma by combined analysis of SNCG, Hiwi, PRL-3, ARD1 and clinicopathologic features in 225 colon adenocarcinoma specimens. Methods: Immunohistochemistry for four tumor markers was performed in whole tissue sections from 225 colon adenocarcinoma patients with complete clinicopathologic data and up to 10-year follow-up. The immunohistochemical expression patterns were examined individually and in multimarker combinations. Univariate and multivariate analyses were done to identify independent predictive markers of poor outcome. Results: With the tumor marker positive rate (32.0％ (62/225) for SNCG, 76.9％ (173/225) for combined SNCG/Hiwi/PRL-3/ARDl) and the detecting accuracy (61.9％ (252/407) for SNCG, 82.6％ (336/407) for combined SNCG/Hiwi/PRL-3/ARDl) raising, incremental value of combined SNCG/Hiwi/PRL-3/ARDl (P < 0.001, HR, 3.2) to poor outcome was found. Stratified by lymph node, Hiwi alone (P =0.004, HR, 3.2) led to poor outcome in patients without lymph node metastasis (LN-), and SNCG (P < 0.001, HR, 2.5) had independently poor prognostic value for patients with lymph node metastasis (LN+). Conclusions: Multimarker phenotypes improved tumor positive rate, detecting accuracy and prognostic value. Additionally, a subgroup of more aggressive tumors can be identified by evaluating Hiwi level in LN- cancer, and SNCG level in LN+ cancer.
colon cancer lymph node metastasis immunochemistry combined analysis
Caiyun Liu Like Qu Xiaofang Xing Tingting Ren Yan Zeng Beihai Jiang Lin Meng Jian Wu Chengchao Shou
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China Department of Biochemistry & Molecular Biology, Peking University Cancer Hospital & Institute,52 Fucheng Road, Haidian District, Beijing 100142, China
国际会议
亚太地区国际肿瘤生物学和医学学术会议、全国肿瘤标志学术大会、第六届中国中青年肿瘤专家论坛
上海
英文
307-320
2011-10-13（万方平台首次上网日期，不代表论文的发表时间）