POLYELECTROLYTE LAYER-BY-LAYER COATING OF CHITOSAN-ALGINATE MICROGELS FOR A NOVEL PULSED DRUG DELIVERY SYSTEM

摘要：

SUMMARY : This report aimed to introduce a novel coremembrane structural drug device suitable for spontaneous pulsed release without any external trigger. The core was prepared through gelatinization between calcium and alginate, treated with chitosan in media at the same time. The swelling pressure of the core, which governs the drug release, mainly comes from the degradation and pH-sensitive of the chitosan-alginate microgels. When the swelling pressure reaches to a critical value, the membrane outside can rupture, accompanied drug massive release. The semipermeable membrane outside the microgel is made of polyelectrolytes including polycation poly (allylamine hydrochloride) (PAH) and polyanion sodium poly (styrene sulfonate) (PSS) sequentially depositing onto the core surface through electrostatic attraction.

关键词： Polyelectrolyte Chitosan-Alginate Microgels Layer-by-layer Pulsed drug delivery

作者: Guichen Zhou Yanqiang Zhong Ying Lu He Zhang Yan Chen Yuan Yu Jing Gao Duxin Sun Guoqing Zhang Hao Zou

作者单位: Department of Pharmaceutical Science, College of Pharmacy, Second Military Medical University 325 Gu Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Ml 48 Department of Pharmacy, East Hospital of Hepatobiliary Surgery, 225 Changhai Road, Shanghai 200438,

会议类型: 国际会议

会议名称: The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)

会议地点: 西安

会议语种:英文

页码: 15-18

在线出版日期: 2011-09-19（万方平台首次上网日期，不代表论文的发表时间）