Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals
Purpose: a novel class of stabilizer—cationic polymer, was introduced into the system of nanocrystals. Methods: Taking itraconazole as a poorly soluble model drug, influence of three cationic polymers, chitosan, N-trimethyl chitosan and polyethyleneimine, on the properties of the nanocrystals prepared by high pressure homogenization method was investigated. Physicochemical properties of the nanoparticles were characterized. Results: It was demonstrated that the cationic polymers could act as both an electrostatic and steric stabilizer to facilitate particle size reduction. Factors influencing charge density and stretching state of the cationic polymers influenced the magnitude of the particle size. The electrostatic stabilization effect is more prominent than that of the steric stabilizing mechanism. Conclusion: The particle size and physical stability of nanocrystals can be adjusted by using different cationic stabilizers.
Nanocrystals Poorly soluble drugs Chitosan N-trimethyl chitosan Polyethyleneimine
Wei Sun Shirui Mao Liang Fang
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
21-22
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）