Combination of 5-fluorouracil and low molecular weight hyaluronic acid improves efficiency of the targeting to tumors
(0) Purpose: To develop a new HA-5-FU conjugates to improves efficiency of the targeting to tumors. Methods: HA-5-FU conjugates were synthesized by using adipicdihydrazide as a linker. Using MTT method of A2780, HepG2, Hela for cell model in vitro to evaluate the antitumor activity of HA-5-FU and 5-FU. Biodistribution of HA-5-FU in tumor-bearing mice was determined by HPLC assay. Results: The inhibition of conjugates to the A2780 and HepG2 cells show the drug was concentration-dependent and time-dependent. Biodistribution in vivo showed that HA-5-FU extended the half life of 5-FU in plasma and the retention time in tumors which demonstrated the targeting to tumors. Conclusion: The HA-5-FU conjugates can extend the circulation time of drugs in plasma and enhance the therapeutic effect of drugs on tumors.
hyaluronic acid 5-fluorouracil cytotoxicity targeting
Z.K. Dong Z.Y. Xu Z.N. Yin
West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
35-36
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）