Effect of ion-pair formation with organic amines on transdermal penetration of lornoxicam in vitro

摘要：

Purpose: The aim of this work was to investigate the percutaneous absorption of lornoxicam (LOX) with organic amines as counter-ions ; Methods: Various organic amines, diethylamine (DEtA), triethylamine (TEtA), triethanolamine (TEA), and N-(2hydroxyethanol)-piperdine (NP), were investigated for promoting the passage of LOX through the rabbit skin in vitro. And ion pair formation between LOX and counter-ions was investigated in solution by IR and H-NMR spectroscopy ; Results: Ion pair formation had an obviously enhancing effect on LOX permeation ; Conclusion : These findings show that ion pair technique is an appropriate method for transdermal application of LOX.

关键词： Lornoxicam Ion pair Transdermal IR H-NMR

作者: Honglei Xi Lin Sun Liang Fang

作者单位: Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China

会议类型: 国际会议

会议名称: The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)

会议地点: 西安

会议语种:英文

页码: 65-66

在线出版日期: 2011-09-19（万方平台首次上网日期，不代表论文的发表时间）