会议专题

Efficacy of surface-modified liposomes for pulmonary delivery of apeptide drug

The aim of this study was to investigate the feasibility of surface-modified liposomes for pulmonary delivery of a peptide. Chitosan oligosaccharide (oligoCS) and polyvinyl alcohol with a hydrophobic anchor (PVA-R) were used as surface modifiers. The effect of liposomal surface modification on the behavior of the liposomes on pulmonary administration and potential toxicity were evaluated in vitro and in vivo. In an association study with A549 cells, PVA-R modification reduced interaction with A549 cells, whereas oligoCS modification electrostatically enhanced cellular interaction. The therapeutic efficacy of elcatonin (eCT) after pulmonary administration to rats was significantly enhanced and prolonged for 48 h after separate administration with oligoCS- or PVA-Rmodified liposomes. oligoCS-modified liposomes adhered to lung tissues and caused opening of tight junctions, which enhanced eCT absorption. On the other hand, PVA-R-modified liposomes induced longterm retention of eCT in the lung fluid, leading to sustained absorption. Consequently, surface modification of liposomes with oligoCS or PVA-R has potential for effective peptide drug delivery through pulmonary administration.

liposomes PVA Chitosan Surface modification Pulmonary administration Elcatonin

Mitsutaka Murata Koji Nakano Kohei Tahara Yuichi Tozuka Hirofumi Takeuch

Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Japan

国际会议

The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)

西安

英文

75-76

2011-09-19(万方平台首次上网日期,不代表论文的发表时间)