High tablettability and good disintegration of novel poly(vinylalcohol-acrylic acid-methylmethacrylate) (POVACOAT(R)) as a granulation binder
(0) Purpose: POVACOAT is a newly developed aqueous polymer which is poly (vinyl alcohol) derivative grafted with acrylic acid and methyl methacrylate. POVACOAT is applied to coating film, granulation binder and solid dispersion carrier etc. This study was focused on the applicability as a granulation binder. Methods: In order to elucidate the wet granulation tendency of POVACOAT, the solid-liquidair packing states of wet massing were evaluated by a mixer torque rheometer (MTR). Hydroxypropylcellulose (HPC-L) was used for comparison. In the next step, the granules obtained with varying the binder liquid amounts were evaluated with regard to tablettability and disintegration. Results: Torque profiles by a MTR suggested that the amounts of POVACOAT as a binder liquid for obtaining the optimized tabletting granules were smaller than that of HPC-L. The tablettability which is defined as tablet hardness against tablet density with varying tabletting pressures was found to be superior in POVACOAT against HPC-L. The disintegration times of tablets were rather faster than that of HPC-L in spite of the higher tablet hardness. These results demonstrated that POVACOAT has an excellent performance as a wet granulation binder with a good balance between the tablettability and disintegration
POVACOAT pharmaceutical excipient granulation binder tablettability disintegration
Shunji Uramatsu Toshinobu Uemura Toshio Shimamoto Dongchun Liu Xing Tang Hideki Ichikawa Yoshinobu Fukumori
Daido Chemical Corporation Kobe Gakuin University, Faculty of Pharmaceutical Sciences Daido Chemical Corporation Shenyang Pharmaceutical University Kobe Gakuin University, Faculty of Pharmaceutical Sciences
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
85-86
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）