Preparation and evaluation of nitrendipine nanocrystals

摘要：

Purpose: To develop a nanocrystal formulation containing nitrendipine nanocrystals for oral delivery. Methods: High pressure homogenization process was employed to prepare the nanocrystals. Results: The prepared nanocrystals significantly improved the solubility and dissolution rate of nitrendipine. The in vivo testing demonstrated that the AUC0→24 of the nanocrystals was approximately 40-fold greater than that of coarse powder. Conclusion: Transformation of nitrendipine coarse powder into nanocrystals is an effective approach to increase the apparent solubility and dissolution rate and, in turn, to enhance the oral bioavailability of nitrendipine.

关键词： Nitrendipine Nanocrystals Preparation Dissolution Bioavailability.

作者: Peng Quan Dengning Xia Hongze Piao Hongyu Piao Kai Shi Fude Cui

作者单位: School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China

会议类型: 国际会议

会议名称: The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)

会议地点: 西安

会议语种:英文

页码: 93-94

在线出版日期: 2011-09-19（万方平台首次上网日期，不代表论文的发表时间）