Preparation and characterization of a hydrophobic derivative of chitosan and its applications as micellar carriers

摘要：

Purpose: To prepare a hydrophobic derivative of chitosan, and use it as a micellar carrier for paclitaxel; Methods: The modified chitosan was synthesized by coupling reaction between a-tocopherol succinate and chitosan. The formation was confirmed by 1H-NMR analysis. Using the probe-type ultrasonic method, PTX-loaded micelles were prepared; Results: In vitro cytotoxicity study revealed the effectiveness of this delivery system; Conclusion: The modified chitosan was a potential micellar carrier for paclitaxel.

关键词： Chitosan α-tocopherol succinate Hydrophobically modified Micelle Paclitaxel

作者: Na Liang Shaoping Sun Hongze Piao Hongyu Piao Fude Cui Liang Fang

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China School of Chemistry and Material Science, Heilongjiang University, No. 74, Xuefu Street, Harbin 1500

会议类型: 国际会议

会议名称: The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)

会议地点: 西安

会议语种:英文

页码: 97-98

在线出版日期: 2011-09-19（万方平台首次上网日期，不代表论文的发表时间）