In vitro characterization of a thermo- and pH-sensitive micelle
Purpose: The purpose of this article was to characterize the thermo- and pH-responsive properties of the micelles constructed from copolymer of poly(LHistidine)-b-poly(DL-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly (DL-lactide-co-glycolide)-bpoly(L-Histidine). Methods: The temperature and pHinduced structure change of the micelles were characterized by an alternation in particle size, a decrease in pyrene florescence intensity and in vitro drug release. Results: The micells showed a temperature- and pH-dependent structural change and drug release profiles. Conclusion: The micelles are feature with thermo- and pH-sensitive properties, which may have great potential to be a smart carrier for anti-cancer drugs.
Thermo-sensitive pH-sensitive Polymeric micelles.
Mingxi Qiao Li Jia Hui Liu Jiawei Qi Haiyang Hu Xiuli Zhao Dawei Chen
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R.China
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
105-106
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）