Nanostructured lipid carriers (NLC) loaded zedoary turmeric oil for parenteral drug delivery: preparation and in vitro evaluation
Purpose: The objective of the present work was to study the preparation and characteristics of Zedoary Turmeric Oil (ZTO), a Traditional Chinese oily Medicine, loaded nanostructured lipid carriers (NLC); Methods: Aqueous dispersions of NLC were successfully prepared by melt-emulsification technique. Properties of NLC such as the particle size and its distribution, the Transmission Electron Microscope (TEM), drug entrapment efficiency and drug release behavior were investigated, respectively; Results: The results indicated the prepared NLC could enhance the drug release rate over the SLN, and the drug release rate could be adjusted by the liquid lipid content in lipid nanospheres; Conclusion: the presented NLC system might be a promising intravenous dosage form of water-insoluble oily drugs.
Xiuli Zhao Kailiang Yang Mingxi Qiao Haiyang Hu Dawei Chen
Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No.103, WenhuaRoad, Shenyang 110016, China
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
107-108
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）