Preparation and characterization of an oral microemulsion of insulin-phospholipid complex
Purpose: The purpose of this study was to prepare and characterize an oral microemulsion of insulinphospholipid complex (IPC). Methods: IPC was prepared by an anhydrous co-solvent lyophilization method. Pseudo-ternary phase diagrams were constructed to optimize the microemulsion system. Phase stability and the type of the microemulsion formulation were investigated by centrifugation test and dye method. The physical characterization of the formulation (physical appearance, viscosity, conductivity and droplet size) were investigated at 4°C and 25°C for 1 month. Results: A porous complex was obtained. The optimal formulation of microemulsion was Cremophor EL/ propylene glycol/ ethyl oleate/ distilled water (17.5: 5.9: 7.8: 68.8, w/w) with a mean droplet size in the range of 20-26nm. No precipitation was observed in the stressed condition and the formulation was O/W. None of the parameters changed significantly during the determined period. Conclusion: This study succeeded in preparing a stable microemulsion formulation of insulin-phospholipid complex.
Insulin Phospholipid complex Microemulsion
Xiongbin Hu Xiuling Lu Tiantian Tang Daxiong Xiang
Key Laboratory of Traditional Chinese medicine preparation, Hunan province, Second Xiangya Hospital Key Laboratory of Traditional Chinese medicine preparation, Hunan province, Second Xiangya Hospital
国际会议
The Second Asian Symposium on Pharmaceutical Sciences and Technology(第二届亚洲药物制剂科学研讨会)
西安
英文
109-110
2011-09-19（万方平台首次上网日期，不代表论文的发表时间）