Wireless Manipulation of Single Cells using Magnetic Microtransporters
For such biomedical applications as single cell manipulation and targeted delivery of chemicals, it is important to fabricate microstructures that can be powered and controlled without a tether in fluidic environments. In this work, we describe the construction and operation of micronsized, biocompatible ferromagnetic microtransporters driven by external magnetic fields capable of exerting forces at the pico Newton scale. We develop microtransporters using a simple, single step micro fabrication technique that allows us to produce large numbers in the same step. We also fabricate microgels to deliver drugs. We demonstrate that the microtransporters can be navigated to separate individual targeted cells with micron-scale precision, and deliver microgels without disturbing the cells in the neighborhood and the local microenvironment.
magnetic actuation microrobot single cell manipulation microgels in vitro
Mahmut Selman Sakar Edward B. Steager Anthony Cowley Vijay Kumar George J. Pappas
GRASP Laboratory,University of Pennsylvania,Philadelphia,PA 19104 Department of Mechanical Engineeri GRASP Laboratory,University of Pennsylvania,Philadelphia,PA 19104
国际会议
2011 IEEE International Conference on Robotics and Automation(2011年IEEE世界机器人与自动化大会 ICRA 2011)
上海
英文
2668-2673
2011-05-09（万方平台首次上网日期，不代表论文的发表时间）