Novel 5,6-Dihydropyrrolo2,1-aisoquinolines as Scaffolds for Synthesis of Lamellarin Analogues

摘要：

As core skeletons of lamellarins: 5,6-Dihydropyrrolo2,1-aisoquinolines are one of the important alkaloids that exhibit significant biological activities, in this study, an e.cient synthetic route was described for two novel compounds, 5,6-dihydropyrrolo2,1- aisoquinolines I and II. Compound I was synthesized from isovanillin with 28.3％ overall yield by a six-step reaction while II from 2-(3,4-dimethoxyphenyl) ethanamine was with 61.6％ overall yield by a three-step reaction. And the structures of these two compounds were confirmed by means of IR spectrum, 1H NMR, 13C NMR, MS, HRMS, and melting point measurements.

作者: Shao Han Liao Dai Hua Hu Ai LingWang De Peng Li

作者单位: College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China Liaoning Ke College of Agronomy, Northwest A&F University, Yangling 712100, China

会议类型: 国际会议

会议名称: 第九届国际海洋生物技术大会

会议地点: 青岛

会议语种:英文

页码: 1-6

在线出版日期: 2010-10-09（万方平台首次上网日期，不代表论文的发表时间）