A Preliminary Study of theMicrobial Resources and Their Biological Activities of the East China Sea
East China Sea is one of the four sea areas in China, which possesses peculiar ecological environment and many kinds of living creatures, especially the microorganisms. We established the East China Sea microorganism library (during 2006?010) for the first time, which stored about 30000 strains that covered most kinds of the species. In this paper, 395 pure strains of East China Sea microorganism library which belong to 33 di.erent genera were mainly introduced. Sulfitobacter, Halomonas, Bacillus, Pseudoalteromonas, and Idiomarina were the most dominant species. On the large-scale biological activity screening of the 395 strains, 100 strains possess di.erent biological activities based on di.erent screening models, of which 11.4％ strains have antibacterial activities, 15.9％ have cytotoxicity activities, and 6.1％ have antioxidation activities. Besides, the secondary metabolites of 6 strains with strong biological activities were studied systematically; diketopiperazines and macrocyclic lactones are the active secondary metabolites. The species and the biological activity of microorganisms diversity, the abundant structure type of the secondary metabolites, and their bioactivities all indicate that East China Sea is a potent marine microorganisms-derived developing resource for drug discovery.
Xiaoling Lu Xiaoyu Liu Cong Long GuoxiangWang Yun Gao Junhua Liu Binghua Jiao
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
国际会议
青岛
英文
1-8
2010-10-09（万方平台首次上网日期，不代表论文的发表时间）