Stimulation Induced Transitions in Spontaneous Firing Rates in Cultured Neuronal Networks also Occur in the Presence of Synaptic Plasticity Blocker KN93

摘要：

Spontaneous firing activity in dissociated rat cortical tissue cultured in vitro shows highly stable firing rates over periods of hours. Recently, it was shown that a short period of low-frequency electrical stimulation induces significant and lasting changes in these firing rates. Now, it is shown that these changes also occur in the presence of the synaptic plasticity blocker KN93 in the culture medium. Apparently, the changes in firing rates after a short period of low-frequency stimulation do not depend on CaMK-Ⅱ mediated synaptic plasticity.

关键词： Cultured networks Spontaneous firing Stable firing rates Attractor dynamics State transitions

作者: Linda van der Heiden Ildiko Vajda Jaap van Pelt Arjen van Ooyen

作者单位: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research,VU University Amsterdam, 1081 HV Amsterdam, The Netherlands

会议类型: 国际会议

会议名称: The Second International Conference on Cognitive Neurodynamics--2009(第二届国际认知神经动力学会议)

会议地点: 杭州

会议语种:英文

页码: 151-156

在线出版日期: 2009-11-15（万方平台首次上网日期，不代表论文的发表时间）