Modelling the Hypothalamic Control of Thalamic Synchronization Along the Sleep-Wake Cycles
Thalamic activity significantly changes at the transitions form conscious wake to unconscious sleep states, going from an unsynchronized single-spike firing to synchronized discharges of impulse groups. These transitions can be simulated with a conductance-based model of neurons and synapses which assumes that alterations of thalamic synchronizations results from the neurons intrinsic dynamics which, however, are externally tuned by synaptic input from sleep-wake controlling areas in the hypothalamus. The crucial role is assigned to activity dependent changes of the synaptic efficacy of the neuropeptide hypocretin/orexin.
Neuronal synchronization Burst discharges Sleep-wake cycles Hypocretin/orexin Synaptic plasticity
Svetlana Postnova Karlheinz Voigt Hans Albert Braun
Neurodynamics Group, Institute of Physiology, University of Marburg, Marburg D-35037,Germany
国际会议
The Second International Conference on Cognitive Neurodynamics--2009(第二届国际认知神经动力学会议)
杭州
英文
563-570
2009-11-15（万方平台首次上网日期，不代表论文的发表时间）