Biodegradation of microcystin-RR by a genetically engineered bacterium
Introduction With increased wastewater discharge containing nitrogen and phosphorus to rivers and lakes, HCBs have become more frequent worldwide. This has led to the destruction of the natural ecological system and production of cyanobacterial toxins such as MCs. MCs produced by Microcystis, Anabaena and Nostoc are the most dangerous toxins to humansl, 2. MCs are monocyclic heptapeptides with Adda responsible for the hepatotoxicity of molecules. More than 70 microcystin isoforms are found in part due to the variable L-amino acids X and Z. And MC-RR is one of the most frequent and studied variants. MCs have been studied extensively, not only for their ability to cause acute poisonings, but also due to their cancer promotion potential by chronic exposure at low concentrations in drinking water. Since the first report of animal death caused by drinking water containing cyanobacteria in 1878, the poisoning and death of aquatic animals, birds, and cattle have been frequently reported. A toxic incident leading to the deaths of over 50 people occurred in Brazil in 1996 due to MCs in the water used for hemodialysis3. MCs are known to be chemically stable compounds 4.
Wang Huasheng Wang Junfeng Ma Song Yan Hai
School of Chemical and Biological Engineering, University of Science and Technology Beijing,Beijing School of Chemical and Biological Engineering, University of Science and Technology Beijing,Beijing
国际会议
北京
英文
149-150
2011-11-24（万方平台首次上网日期，不代表论文的发表时间）