A 2D Analysis of Oxygen Transportation in a Novel Bioreactor Based on Oxygen Carrier for Bio-artificial Liver Support System
Bioreactor (BR) is the key component of bioartificial liver support system (BALSS). Sufficient mass transfer in BR is of great importance for hepatocytes and is essential to BALSS fine quality. In this paper, a mathematical model describing oxygen distribution in a suspension BR with perfluorocarbons (PFC) called oxygen carrier was developed to obtain the most efficient BR operating parameters. The 2D model is based on the geometry of BR operated under unsteady-state conditions, and the BR which rotates periodically has two inlets and outlets working alternatively. The model equations are solved using the finite element software (Fluent). The calculated results of oxygen distribution showed that 200 ml/min to 400 ml/min inlet velocity with 0.3 min to 0.5 min BR rotation period could lead to an efficient oxygen distribution.
Mei Mei Duan Chang Zhe Wu Xiao Lin Huo Ming Li
Institute of Electrical Engineering, Chinese Academy of Sciences
国际会议
2011 International Symposium on Bioelectronics and Bioinformatics(第二届国际生物医学电子学与生物信息学学术会议 ISBB 2011)
苏州
英文
123-126
2011-11-03（万方平台首次上网日期，不代表论文的发表时间）