Quantification of Collagen Alteration in Mid-dermis of Skin Lesion with Mucinosis using Second Harmonic Generation Imaging
Cutaneous mucinoses are a heterogeneous group of diseases characterized by abnormal deposition of dermal mucin. Considering the collagen disorder due to the mucin deposition, collagen microstructure was visualized by second harmonic generation (SHG) microscopy to gain structural and diagnostic information. High resolution images of collagen in the dermis of skin lesion with mucinosis and healthy skin showed differences in their microstructures. SHG density as well as depth dependant decay coefficient was analyzed to quantitatively characterize the microstructure. Our results demonstrated the possibility of SHG imaging to in vivo tracking the pathological process of mucinoses and evaluate the therapeutic efficacy.
Lihang Lin Xiaoqin Zhu Haibo Yu Jianxin Chen
Institute of Laser and Optoelectronics Technology,Fujian Provincial Key Laboratory for Photonics Tec Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Te Institute of Laser and Optoelectronics Technology,Fujian Provincial Key Laboratory for Photonics Tec
国际会议
2011 International Symposium on Bioelectronics and Bioinformatics(第二届国际生物医学电子学与生物信息学学术会议 ISBB 2011)
苏州
英文
159-161
2011-11-03（万方平台首次上网日期，不代表论文的发表时间）