An New Method for Frontier Port Pathogenic Microorganism Detection Gene chip Probe Design

摘要：

In process of genechip probe design for Pathogenic microorganism detection, the selection of SNP combination is of great importance. At present, no automatic design method is reported. This work is not easy and the result is not always satisfactory. A new approach of selecting SNP combination is proposed in this paper. Genetic algorithm is used to search optimal solution on the basis of classification ability of SNP combination, which is evaluated by the rough set theory. Other related experimental parameters are also been incorporated. Experiment results show that the method can get the best SNP combination pattern efficiently and accurately, which promises it a reliable approach for the genechip probe design.

作者: Lu Lin Che Zhijun Liu Guochuan Wang Fei

作者单位: Beijing Entry-exit Inspection and Quarantine Bureau,Beijing, CO 100026 China Beijing Entry-exit Inspection and Quarantine Bureau, Beijing, CO 100026 China

会议类型: 国际会议

会议名称: 2011 International Symposium on Bioelectronics and Bioinformatics(第二届国际生物医学电子学与生物信息学学术会议 ISBB 2011)

会议地点: 苏州

会议语种:英文

页码: 247-250

在线出版日期: 2011-11-03（万方平台首次上网日期，不代表论文的发表时间）