GOLD NANOPARTICLES WITH DIFFERENT SIZE AS ASSISTED MATRIX FOR THE DETECTION OF SMALL MOLECULES THROUGH LASER DESORPTION/IONIZAnON TIME-OF-FLIGHT MASS SPECTROMETRY

摘要：

In this paper, citrate-capped AuNPs with different size are used as assisted matrix for the detection of small molecules. The small AuNPs (～17 nm) was more stable and more efficient as matrix than large AuNPs (～50 nm), especially in a high-salt solution. We also used AuNPs (～17 nm) for the detection of various small molecules, which have different aquatic solubility. The detection of small molecules which are not soluble in water, by LDI—TOF MS with the matrixes of AuNPs, was very difficult and requires further work.

关键词： Gold nanoparticles laser desorption/ionization time-of-flight mass spectrometry matrix small molecules size

作者: Qiu Fei Huang Lequn Lee

作者单位: Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China Molecular Medicine Engin Institute of Molecular Medicine, Nanjing University, 22 Hankou Road, Nanjing 210093, China

会议类型: 国际会议

会议名称: The 7th International Forum on Post-Genome Technologies and China-Japan-Korea Summit on Natural Products(第七届国际后基因组技术论坛及中日韩天然产物论坛 IFPT)

会议地点: 重庆

会议语种:英文

页码: 103-105

在线出版日期: 2011-10-28（万方平台首次上网日期，不代表论文的发表时间）