DIFFERENTIAL HUMORAL RESPONSE OF GENOTYPE IB HEPATITIS C VIRUS F PROTEIN BETWEEN CHRONIC AND RECOVERED INFECTIONS
This study is to investigate the differential humoral response of anti-F antibodies between chronic and recovered infections. Genotype 1b HCV F protein was used as coated antigen to assess the prevalence and the antibody titer of anti-F in plasma from 42 chronic HCV patients, 19 recovered individuals from HCV infection, and 10 healthy volunteers. The anti-F humoral response in 25 samples showed a significantly higher reactivity in chronic than that in recovered HCV infections. Anti-F antibody titers were also significantly higher in chronic patients than that in recovered individuals. There are no significant differences of anti-F antibody titers between recovered patients and healthy volunteers. The different response of genotype 1b HCV F protein between chronic patients and recovered individuals, and the cross-reactivity irrespective of genotype 1b HCV F protein demonstrated that the F protein might play an important role in the pathogenesis of natural HCV infection.
genotype 1b Hepatitis C virus(HCV) humoral response F protein C protein
Deng Xiaozhao Kong Jing Chu Chunli Zhang Jinhai Yue Ming Lu Weidong Zhang Yun
Huadong Research Institute for Medicine and Biotechniques, Nanjing 210002, China Huadong Research Institute for Medicine and Biotechniques, Nanjing 210002, China Huaiyin Institute o Huaiyin Institute of Technology, Huaian 223003, China Kunming Medical College, Kunming 650031, China
国际会议
重庆
英文
165-167
2011-10-28（万方平台首次上网日期，不代表论文的发表时间）