ROLE OF NOTCH SIGNAL IN NEURAL DIFFERENTIATION OF HMSCS INDUCED BY SODIUM FERULATE
Mesenchymal stem cells (MSCs) derived from bone marrow are undifferentiated cells that have the ability to self-renew with a high proliferative capacity and possess pluripotency potential to differentiate into cells of diverse lineages within the body. In this paper, we revealed that Sodium Ferulate (3-methoxy-4-hydroxy-cinnamate sodium, SF) could induce hMSC to differentiate into neuroal-like cells effevtively. Furthermore, we analyzed the expression levels of Notchl in induced cells to investigated the possible mechanism involved in the neural differentiation induced by SF. The results showed significantly down-regulation of Notchl expression in cells treated by SF. It indicated that Notch signaling pathway may contribute to the neural differentiation of hMSCs induced by SF.
MSCs Sodium Ferulate neural differentiation
Deng Zhifeng Lou Yuanlei Tu Wei Lai Xianliang Gong Feixiang Guo Ye Wang Yang
Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Institute of Urology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
国际会议
重庆
英文
217-219
2011-10-28（万方平台首次上网日期，不代表论文的发表时间）