DIFFERENTIAL EXPRESSION AND TARGET PREDICTION OF MICRORNAS IN HIPPOCAMPUS IN SEVOFLURANE-ANESTHETIZED RATS
MicroRNAs (miRNAs), as endogenous regulators of gene expression, play an important role in many physiological and pathological processes. Here, expression profile of 6 miRNA family (13 miRNAs), including tniR-132, miR-183, miR-133, miR-29, miR-10 and miR-223 family, were investigated in hippocampus in sevoflurane-anesthetized rats. These miRNA were all expressed in hippocampus and sevoflurane anesthesia induced a time-dependent, but not dosedependent expresion change for 6 miRNA family. The expression difference of miR-10a, miR-223, miR-133a and miR-451 were most significant. Bioinformatic analysis indicated that Laspl, Gpm6, Slc6al and ACSL3 for miR-133a; Mtpn, Lmo2 and Rnf34 for miR-223; BDNF, SDC1 and ELAVL2 might be targets for miR-10a. But, targets of miR-451 did not be found. Although predictions had not been experimentally validated, these data should be benefit for illustrating the role of miRNA in memory impariment induced by sevoflurane anethesia.
MiRNA Memory impairment Sevoflurane Hippocampus
Pan Zhiqiang Li Yangqiang Hao Lingyun Zhu Lijiao Zhang Licai Yang Junxia Cao Junli
Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China Jian Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China Jian
国际会议
重庆
英文
285-287
2011-10-28（万方平台首次上网日期，不代表论文的发表时间）