PHYLOGENETIC ANALYSIS OF ASPM, A BRAIN-VOLUME-RELATED GENE IN VERTEBRATES

摘要：

Bioinformatics analysis was carried out to compare nucleotide and protein sequences of ASPM (abnormal spindle-like microcephaly-associated protein), a brain-volume-related gene from nine vertebrate species to identify genetic variations that might have shaped the evolution of brain volume and underlying microcephaly malformation. Based on anatomy of brain structure, 9 species were selected. Alignment of protein and nucleotide sequences indicated that exon 18 of the ASPM gene to be the longest coding sequence and is rich in genetic variations. The number of IQ domain repeats contained in this exon seems to correlate with the brain volume. Based on the consistency between phylogenetic trees structured with molecular sequences and comparative anatomy, exon 18 of the ASPM gene may contribute to the increase of brain volume during vertebrate evolutioa

关键词： ASPM gene Brain volume Sequence alignment IQ domain Exon

作者: Ye Yu Zhang Jingshu Jesse Liling

作者单位: Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110819, Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110819,

会议类型: 国际会议

会议名称: The 7th International Forum on Post-Genome Technologies and China-Japan-Korea Summit on Natural Products(第七届国际后基因组技术论坛及中日韩天然产物论坛 IFPT)

会议地点: 重庆

会议语种:英文

页码: 363-365

在线出版日期: 2011-10-28（万方平台首次上网日期，不代表论文的发表时间）