SNP RS2470152 IN CYP19 IS CORRELATED TO AROMATASE ACTIVITY IN CHINESE PCOS WOMEN
CYP19 encodes aromatase, a key enzyme essential for estrogen biosynthesis. Single Nucleotide polymorphism (SNP) rs2470152 in CYP19 is associated with serum estradiol (E2) level and E2/T (estradiol/ testosterone) ratio. A case-control study including 661 individuals (364 PCOS patients and 297 controls) was conducted to assess the association of SNP rs2470152 with PCOS. All subjects were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Hormone levels were analysed among different genotypes. The genotypic distributions of rs2470152 did not differ in PCOS patients from controls. However, Differences of E2/T ratio were detected, exhibiting lower ratio in heterozygous TC genotype both in PCOS patients (p=0. 010 36) and controls (/>=0. 000). Testosterone levels also differed in three genotypes of PCOS patients (p=0. 006 25), with a higher level in TC genotype. Therefore, rs2470152 in CYP19 was not a major etiological factor for PCOS, but heterozygous TC genotype may inhibit aromatase activity, resulting in hyperandrogenism especially in PCOS patients.
PCOS CYP19 SNP rs2470152 aromatase activity
Zhang Xinl Yi Long Gao Qian Wang Yong Zhang Chengw Xu Pei Liang Fengj Che Yen Xia Yanj Cao Yunx Wu Xiaok Wang Wenj
Center for Translational Medicine & Jiangsu Key Laboratory of Molecular Medicine, Medical School of Department of Obstetrics and Gynecology, Anhui Medical University, Hefei 230022, China Department of Obstetrics and Gynecology, the First Affiliated Hospital, Heilongjiang University of C Centre of Reproduction, Department of Obstetric & Gynaecology, Memorial Hospital of Sun Yat-Sen Univ
国际会议
重庆
英文
396-399
2011-10-28（万方平台首次上网日期，不代表论文的发表时间）