PHYLOGENETIC CHARACIERIZAnON OF HANTAVIRUSES FROM WILD RODENTS IN SOUTHEAST COASTAL REGION OF CHINA, 1981—2007
Objective To investigate the genomic variability of Hantavirus (HV) isolates from different hosts and different locations in southeast coastal region of China in 1981—2007. Methods The entire M and S segments of the HV genome were amplified using reverse transcription (RT) polymerase chain reaction (PCR) and were analyzed by Phylogenetic trees using DNAstar and MEGA 4. 0. Result ()f the 12 HV strains, five were classified as HTNV and the others as SEOV. In HTNV isolates from the same region shared high degree of sequence identity and clustered on the same branch of Phylogenetic trees respectively while isolates from different districts were clustered on the adjacent branches. Of the 7 strains of SEOV, two isolates from Jiande county in Zhejiang province were clustered on a separated branch, which has wider sequences variability than the others. Conclusion The HV sequence variation may owe more to the regional than temporal or host disparity, particularly for HTNV.
hemorrhagic fever with renal syndrome (HFRS) Hantavirus sequence analysis evolution host switchover
Yao Pingping Xiong Hairong Zhang Yun Zhu Hanping Deng Xiaozhao Cao Min Xu Fang Xie Ronghui Weng Jingqing Zhu Zhiyong Yang Zhanqiu
Zhejiang Center for Disease Prevention and Control (CDC), Hangzhou 310051, China School of Medicine, Wuhan University Wuhan 430071, China Military Institute for medicine of Nanjing command, Nanjing 210002, China
国际会议
重庆
英文
419-422
2011-10-28（万方平台首次上网日期，不代表论文的发表时间）