ATOMIC FORCE MICROSCOPY INVESTIGATION OF THE MORPHOLOGY AND MECHANICAL PROPERTIES OF CELL RESPONSE TO ANTIBIOTIC TREATMENT

摘要：

Atomic force microscopy (AFM) was used to investigate the morphology and mechanical properties of HeLa cells in response to antibiotic treatment. The results showed that the cell shape, surface roughness and mechanical properties were all changed in the presence of nystatin, which were consistent with the mechanism of action of the drug. This work demonstrated that AFM was a useful tool for studying the interaction between drugs and cells.

关键词： Atomic force microscopy Morphology Mechanical property Antibiotic

作者: Wang Qing Chen Tong Yang Xiaohai Wang Kemin Wu Chunling Liu Wei Zhou Chenchen

作者单位: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering,Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, ChangSha China

会议类型: 国际会议

会议名称: The 7th International Forum on Post-Genome Technologies and China-Japan-Korea Summit on Natural Products(第七届国际后基因组技术论坛及中日韩天然产物论坛 IFPT)

会议地点: 重庆

会议语种:英文

页码: 425-427

在线出版日期: 2011-10-28（万方平台首次上网日期，不代表论文的发表时间）