SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN BASED HYBRID BIOPOLYMER SCAFFOLD

摘要：

Current tissue engineering strategies are focused on the restoration of pathologically altered tissue architecture by transplantation of cells in combination with supportive scaffolds and biomolecules.Biodegradable polymers and bioactive ceramics are being combined in a variety of composite materials for tissue engineering scaffolds.A scaffold is an artificial structure capable of supporting three dimensional tissue formation which mimics like extracellular matrix.Here we report on the development of a biodegradable scaffold made from naturally derived chitosan along with some anionic polymer like gelatin, alginate, hyaluronic acid etc.While the natural polymer chitosan imparts its unique properties of biodegradability, antifungal nature, nontoxicity, biocompatibility.the anionic polymers due to bonding with chitosan not only contribute to enhanced mechanical strength but also increased biocompatibility.This paper investigates the right combination of desired properties like enhanced mechanical properties and biocompatibility in scaffold because of composite nature.

关键词： Carboxymethyl chitosan Tissue engineering Scaffold Biopolymer

作者: LAXMI UPADHYAYA RAKESH MATHUR R.P.TEWARI

作者单位: Department of Applied Mechanics MNNIT,Allahabad,India Department of Applied Mechanics,MNNIT,Allahabad,India

会议类型: 国际会议

会议名称: 3rd International Conference on Mechanical and Electrical Technology(ICMET2011) (2011第三届机械与电气技术国际会议)

会议地点: 大连

会议语种:英文

页码: 767-772

在线出版日期: 2011-08-26（万方平台首次上网日期，不代表论文的发表时间）