Synthesis and Anti-tumour Activity in Vitro of Camptothecin-Bile ACID analogues

摘要：

Aim: Synthesis a series of camptothecin-bile acids derivatives. Method: Bile acid were combined with camptothecin by ester reaction at the presence of double agent. Result: Some of these derivatives showed cytotoxic activity comparable to that of camptothecin in human liver and colon cancer cells. The cytotoxic activities of these derivatives against bile acid-negative Hela cells were much lower than that against the bile acid- positive liver and colon cancer cells. The lactone stability of these tested derivatives in rat blood serum was generally improved.

关键词： Camptothecin Bile acids Liver cancer

作者: Yang Gao Wei Qiu Qing-yong Li Yuan-gang Zu Wu-na He

作者单位: Key Laboratory of Forest Plant Ecology Northeast Forestry University, Ministry of Education, Harbin city, Heilongjiang Province, PR China

会议类型: 国际会议

会议名称: International Conference on Bioinformatics and Biomedical Technology(ICBBT 2011)(2011年生物信息与生物医药技术国际会议)

会议地点: 三亚

会议语种:英文

页码: 217-219

在线出版日期: 2011-03-25（万方平台首次上网日期，不代表论文的发表时间）