Amniotic Membrane Loading Epidermal Stem Cells Accelerate Impaired Wound Healing in Diabetic Rats

摘要：

Epidermal stem cells are essential in wound healing, but their amount and activity are decreased in diabetes which contributes to the impaired healing. This study evaluated the efficacy of amniotic membrane loading epidermal stem cells in the management of impaired wound in diabetes. Epidermal stem cells derived from SD rats were isolated, cultured, identified and tabled with BrdU in vitro. The wound model of diabetic rats were established, then amniotic membrane loading tabled BrdU epidermal stem cells were implanted to impaired wound. The results showed that wound healing rate in amniotic membrane loading epidermal stem cells was significantly higher than that in control groups 14 days after treatment. BrdU-positive cells in the wounds and newborn epidermis were visible. This indicated that amniotic membrane loading epidermal stem cells accelerates epidermal migration of wound margin and wound epithelialization in diabetic rats.

关键词： amniotic membrane epidermal stem cell transplantation wound healing diabetes mellitus rat

作者: Qingling Zhong Dewu Liu Fanrong Liu

作者单位: Medical College of Nanchang University,Nanchang,China Institute of Burns,First Affiliated Hospital o Institute of Burns,First Affiliated Hospital of Nanchang University,Nanchang,China Medical College of Nanchang University,Nanchang,China

会议类型: 国际会议

会议名称: the 2011 International Conference on Key Engineering Materials(ICKEM 2011)(2011关键工程材料国际会议)

会议地点: 三亚

会议语种:英文

页码: 455-460

在线出版日期: 2011-03-25（万方平台首次上网日期，不代表论文的发表时间）