Computer-Aided Homology Modeling of TbpA Protein from Actinobacillus Pleuropneumoniae

摘要：

TbpA is a highly conserved transmembrane protein that may serve as a channel for transport of iron across the outer membrane,which is required for transferrin utilization and is responsible for removing the iron from transferrin and for transporting iron across the outer membrane in a TonB-dependent manner.In the present study,a 3D homology modeling of TbpA from Actinobacillus pleuropneumoniae (App) L20 strain,based upon the Crystal structure of the hcmehcmoglobin outer membrane transporter ShuA from Shigella dysenteriae (PDB code:3fhh) was performed using bioinformatics tools,as no experimental 3D structures.The program VERIFY 3D assessed the quality of the predicted structure of TbpA with acceptable scores.All the results converged to the fact that the predicted 3-Dimenrsional structure of TbpA is of good quality with acceptable scores.

关键词： component Computer-aided Actinobacillus pleuropneumoniae homology modeling

作者: Ren-Feng LI Kun ZHAO Xue-Bin LI Jin-Qing JIANG San-Hu WANG

作者单位: Henan Institute of Science and Technology Xinxiang,453003,P.R.China

会议类型: 国际会议

会议名称: 2011 3rd International Conference on Computer and Network Technology(ICCNT 2011)(2011第三届IEEE计算机与网络技术国际会议)

会议地点: 太原

会议语种:英文

页码: 612-614

在线出版日期: 2011-02-26（万方平台首次上网日期，不代表论文的发表时间）