Computer-aided Design and Fabrication of Bio-mimetic Materials and Scaffold Micro-structures

摘要：

Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.

关键词： Bio-mimetic materials Computer-aided design (CAD) Solid free-form fabrication (SFF) Homogenization method, Scaffold Tissue Engineering

作者: Yuhang Chen Joseph Cadman Shiwei Zhou Qing Li

作者单位: School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Australia

会议类型: 国际会议

会议名称: 2011 International Conference on Advanced Material Research(ICAMR 2011)(2011年先进材料研究国际会议)

会议地点: 重庆

会议语种:英文

页码: 628-632

在线出版日期: 2011-01-21（万方平台首次上网日期，不代表论文的发表时间）