Zebrafish: A Predictive Model for Assessing Developmental Toxicity and Teratotoxicity of Compounds

摘要：

Conventional assessment of developmental toxicity and teratotoxicity in mammalian models is laborious and time consuming. Zebrafish is emerging as an alternative vertebrate animal model for assessing toxicity and safty of compounds,in part due to its transpatency,rapid development,and simplicity of compound delivery. In this study,we characterized developmental toxicity and teratotoxicity of 7 known mammalian teratogenic compounds and 3 mammalian nonteratogenic compounds in zebrafish. A 100% correlation between developmental toxicity and teratotoxicity observed in zebrafish and findings in mammalian models was found. Our data suggest that zebrafish is a simple,reproducible,cost-efficient and highly predictive animal model for assessing compound-induced developmental toxicity and teratotoxicity.

作者: Rujia CHEN Junjing ZHU Xiaoyu ZHU Yong ZHANG Chunqi LI

作者单位: Hunter Biotechnology,Inc.,Transfarland,Xiaoehan Economic & Technology Development Zone,Hangzhou City,311231,China

会议类型: 国际会议

会议名称: The 5th Session of the 13th Annual Meeting,CAST International Conference on Chemicals Risk Assessment of Environmental Hazard and Human Health(第13届中国科协年会第5分会场：化学物的环境危害与健康风险评估国际研讨会)

会议地点: 天津

会议语种:英文

页码: 44-46

在线出版日期: 2011-09-20（万方平台首次上网日期，不代表论文的发表时间）