Propoxur Induced Immuntoxicity on Balb/c Mice
(0) Propoxur is a widely used carbamate insecticide applied mainly for pest control in households in many countries. In order to evaluate the immnotoxicity of propoxur mice were exposed to propoxur at the dose of 0.7-10 mg/kg for 30 days. At the end of experiment the body weights of mice were measured, and the immune system damage were evaluated through spleen and thymus weight, killing ability of natural killer cell, plaque forming cell assay (PFC) , serum hemolysin detection, T lymphocyte proliferation and delayed-type-hypersensitivity (DTH). The result showed that propoxur could decreased the thymus organ index and PFC at the dose of 5.0 mg/kg. It also inhibited the T lymphocyte proliferation and NK cell killing activity at 2.5 mg/kg. Especially for spleen organ index, it was influenced by propoxur at the dose of 1.3 mg/kg. The DTH of mice was not influenced by propoxur at the dose of 10 mg/kg. Based on these information it was drawn that propoxur had adverse effect on immune system. Both innate immune system and adaptive immune system were influenced while mice exposed to propoxur for one month.
Xuetao WEI Yangzheng QIAO Yan ZHAO Changfu HAO Qingkun SONG Jianjun JIANG Lanqin SHANG Weidong HAO
Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety,Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, China
国际会议
天津
英文
127-130
2011-09-20（万方平台首次上网日期，不代表论文的发表时间）