Effects of Silver Nanoparticles on the Immune System of Rat
ObjectionTo study the effects of silver nanoparticles(Nano-Ag) on the immune system of rat. MethodIn this study, Rats were exposed by intratracheal instillation to various doses (3. 5 and 17. Smg/kg body weight) of Nano-Ag once two days for 5 weeks, calf serum as negative control. The body weight changes and immune organ coefficients changes were checked. The pathological examinations of rat livers, kidney, spleen and thymus were performed to reflect the substantial changes, peripheral blood serum were also collected to detect the count of cell classification(whole blood count) and T lymphocyte subsets. Result the body weight of rats in low and high doses of Nano-Ag groups significantly decreased, while the immune organ coefficients and histopathology have no significantly changes; Significant changes were observed (P < 0. 01) in hematological parameters (WBC count, RBC count, and LYO (%)) in the 17. Smg/kg groups, in RBC count in the 3. Smg/kg groups. The changes were non-significant in the other groups (3.5 and 17. Smg/kg group). The analysis of T cell subsets in peripheral blood showed that CD4+Tcell subsets and the CD4+/CD8+ratio were decreased, while the CD8+T cell subsets increased remarkably in rate as compared with control. Conclusion Taken together, the findings suggest Nano-Ag could lead to disorder in immune homeostasis of rats.
HonglianYANG Huangliang LIU Huashan ZHANG Danfeng YANG Zhuge XI
Tianjin Insititute of Health and Environmental Medicine, Tianjin , 300050, China
国际会议
天津
英文
143-145
2011-09-20（万方平台首次上网日期，不代表论文的发表时间）