会议专题

Drug Transporter-mediated Pharmacokinetics and Toxicities

Drug transporters are expressed ubiquitously in tissues, such as the intestine, liver, kidney, and brain, and play an important role in drug absorption, distribution, elimination of most xenobiotics, drugs, environmental toxins, as well as their metabolites. In clinical, it can affect the pharmacokinetics by transporter-drug-drug interactions and/or produce toxic effects by transporter* dependent inhibition. Function characteristics of drug transporters and transporter-based toxicity study will provide helpful information to enhance drug delivery efficiency or design novel drug by targeting specific transporter. In this presentation, the significant role performed by human drug transporter in drug disposition and toxicity will be fully discussed,focusing on their potential application at the stage of drug discovery and development.

XiulinYI Changxiao LIU

Tianjin Institute of Pharmaceutical Research,Tianjin Center for Drug Evaluation and Safety Research, State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin,300193,China

国际会议

The 5th Session of the 13th Annual Meeting,CAST International Conference on Chemicals Risk Assessment of Environmental Hazard and Human Health(第13届中国科协年会第5分会场:化学物的环境危害与健康风险评估国际研讨会)

天津

英文

149-151

2011-09-20(万方平台首次上网日期,不代表论文的发表时间)