The Effects of Low-level Arsenic Exposure on Erythrocyte Membrane Proteins in Male Rats

摘要：

The rats were exposed to arsenic in drinking water (10, 60, 360μg/L) for 30 days. As shown in SDS-PAGE, compared with the control group, ankyrin content was significantly decreased in 360μg/L dose group. With exposure levels rising, band 3 protein expression presented an increasing trend in the treated groups. Immunofluorescence analysis revealed that, in 60μg/L and 360μg/L arsenic treatment groups, band 3 and CD3S increased and clustered to the RBC membrane. The results for rat erythrocyte parameters revealed that the abnormal changes have not occurred in the exposed groups. This study suggests that the injuries in RBC membrane proteins occur earlier than the abnormal changes in RBC number and volume. Erythrocyte membrane proteins may be the early biomarkers of chronic arsenic poisoning.

作者: Jing ZHANG Zhifeng MA Yi GAO Fengjie TIAN Ning MA Qiuling PEI

作者单位: Department of Health Toxicology, School of Public Health, Shatni Medical University, Taiyuan 030001, Faculty of Health Science and Institute of Traditional Chinese Medicine, Suzuka University of Medica

会议类型: 国际会议

会议名称: The 5th Session of the 13th Annual Meeting,CAST International Conference on Chemicals Risk Assessment of Environmental Hazard and Human Health(第13届中国科协年会第5分会场：化学物的环境危害与健康风险评估国际研讨会)

会议地点: 天津

会议语种:英文

页码: 163-166

在线出版日期: 2011-09-20（万方平台首次上网日期，不代表论文的发表时间）