Effect of Nano-alumina on Cognitive Alternations of Animal in vivo
The rapid development and expanding applications of nanotechnology have led to enhanced exposure of human body to nan-oparbcles through four possible routes; inhalation of airborne nanoparticles, ingestion of drinking water or food additives, dermal penetration by skin contact, and injection of engineered nanomaterials. It is, therefore, necessary to address the safety issue via rigorous toxicological evaluation and to understand the underlying interaction mechanism. Such toxicological studies can provide useful information on not only the biological applications of nanoparticles, but also any undesirable toxic effects. However, only a few studies to date have evaluated the safety of nanosized materials and their potential adverse effects on biological systems. In this study, we sought to investigate the potential toxicity of aluminum oxide (alumina) nanoparticles in SD rats, focusing on potential neurobehavioral defects and the possible mechanisms. Male SD rats were administrated with nano-carbon and nano-alumina with a mean particle size of about 50 run by intranasal administration. Changes in neurobehavior, mitochondrial membrane potential (MMP) , reactive oxygen species (ROS), cell death rates and expression of cell death related genes were analyzed by the Morris method, flow cytometry, and qRT-PCR, respectively. These analyses demonstrated that nano-alumina impaired neurobehavioral functions and induced cell necrosis and apoptosis, likely mediated by the reduction in MMP and ROS and the induction of the caspase-3 gene. Collectively, these results show a strong pro-cell death effect of nano-alumina on SD rats in vivo, suggesting that nano-alumina may serve as an inducer for neural toxicology.
Qinli ZHANG Meiqin LI Feilin REN Ce ZHANG Qiao NIU
Department of Occupational Health, School of Public Health, Shanxi Medical University,Taiyuan,030001 Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan,03000
国际会议
天津
英文
171-175
2011-09-20（万方平台首次上网日期，不代表论文的发表时间）