Study of Biomarker among Polycyclic Aromatic Hydrocarbons Exposed Workers

摘要：

The purpose of this study was to address the association between the ataxia-telangiectasia mutated (ATM) gene polymorphisms and susceptibility to DNA repair capacity (DRC) among polycyclic aromatic hydrocarbons (PAHs) -exposed workers. DRC was determined by comet assay. Chromosomal damage was detected by cytokinesis-block micronucleus (CBMN) assay. Subjects carrying T allele of rs228S89 had significantly lower DRC compared to those with AA genotype. Subjects carrying G allele of rs652311 had significantly lower DRC compared to those with AA genotype. Individuals with one copy of haplotype CGGT had significantly lower DRC than those with zero copy of haplotype CGGT. In conclusions, ATM polymorphisms are associated with DRC among PAHs-exposed workers and ATM plays key roles in repair of chromosomal damage.

作者: Yadong WANG Juan CHENG Huawei DUAN Ping BIN Yufei DAI Chuanfeng HUANG Yuxin ZHENG

作者单位: National Institute of Occupational Health and Poison Control,China CDC,Beijing,700050,CHina

会议类型: 国际会议

会议名称: The 5th Session of the 13th Annual Meeting,CAST International Conference on Chemicals Risk Assessment of Environmental Hazard and Human Health(第13届中国科协年会第5分会场：化学物的环境危害与健康风险评估国际研讨会)

会议地点: 天津

会议语种:英文

页码: 183-185

在线出版日期: 2011-09-20（万方平台首次上网日期，不代表论文的发表时间）