Modeling the Mammalian Circadian Clock with Transcriptional Feedback Loops and cAMP Signaling

摘要：

In this paper,we construct a new mathematical model by incorporating both transcriptional/translational feedback loops and cAMP-mediated feedback loop into the mammalian circadian oscillator.Except for reproducing typical experimental observations,the model shows that (i)for a weak TTFL,cAMP can sustain transcriptional rhythms of the mammalian circadian clock,(Ⅱ)for a strong TTFL,cAMP can only modulate the period and amplitude of transcriptional rhythms.The authors conclude that to understand the timekeeping mechanism of suprachiasmatic nucleus neurons,the transcriptional feedback loops should not be isolated from intracellular cAMP-dependent signaling.

作者: WANG Junwei CHEN Aimin

作者单位: School of Informatics,Guangdong University of Foreign Studies,Guangzhou 510006,P.R.China Institute of Applied Mathematics,Henan University,Kaifeng 475004,P.R.China School of Mathematics and

会议类型: 国际会议

会议名称: The 30th Chinese Control Conference(第三十届中国控制会议)

会议地点: 烟台

会议语种:英文

页码: 1-6

在线出版日期: 2011-07-01（万方平台首次上网日期，不代表论文的发表时间）