Cellular Communication-Induced Dynamics in a Multicellular System
Traditionally,the main role of cell-cell communication was thought of as synchronizing a population of cells,thereby coordinating cellular behavior.Here,we show that cell density,which quanti es cellular communication,can induce multi-stability and multirhythmicity in a synthetic multicellular system,where individual oscillators are a merge of repressilator and hysteresis-based oscillator and are coupled through a quorum-sensing mechanism.Speci cally,for moderately small cell densi-ties,the coupled system can exhibit multistability including stable homogenous and inhomogeneous steady states.For moderately large cell densities,it has potentials to generate multirhythmicity including multi-mode oscillations such as in-phase period-1 oscillation,antiphase period-2 oscillation,asymmetric period-2 oscillation,and oscillations with mixed modes,coexistence of periodic orbits of several different modes,and bursting oscillations such as periodic bursting,torus quasi-periodic bursting,and chaos.Such versatility of cell-cell communication would be bene cial for cells or organisms to live in diversely changeable environments.
YI Qizhi DU Yan
School of Mathematics and Information Science,Jiangxi Normal University,Nanchang 330022,P.R.China Sc School of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022,P.R.China
国际会议
The 30th Chinese Control Conference(第三十届中国控制会议)
烟台
英文
1-7
2011-07-01（万方平台首次上网日期，不代表论文的发表时间）