Topologies Needed For Perfect Adaptation

摘要：

It is now being greatly studied for the relationship between the topologies of biological networks and their functions. However, previous studies on network topologies underlie certain biological function are all based on specific mechanisms or dynamics. Here, using a very general mathematical description, we investigate the topologies needed for perfect adaptation-a core function for living creatures in nature, just based on the interactions relationship among nodes: promotion, inhibition, and no relation. We find a necessary interactions relationship among nodes for the network to achieve perfect adaptation. And using this necessary condition, we can conclude that the coherent feedforward loop is incapable of performing perfect adaptation function and show that the saturation condition for the key protein CheR in the network of E. coli chemotaxis is essential.

作者: SU Wei

作者单位: Key Lab.of Systems & Control, AMSS, Chinese Academy of Sciences, Beijing 100190, P.R.China

会议类型: 国际会议

会议名称: The 30th Chinese Control Conference(第三十届中国控制会议)

会议地点: 烟台

会议语种:英文

页码: 1-4

在线出版日期: 2011-07-01（万方平台首次上网日期，不代表论文的发表时间）