Biological Safety Assessment of A Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests
Objective: To evaluate the biological safety of a colored zirconia ceramic in terms of cellular toxicity and a skin sensitivity test. Methods: the cytotoxicity of the ceramic was evaluated by a molecular filtration method and skin irritation activity of the composite was assessed via intradermal injection of a guinea pig test solution, by inducing, enhancing, and stimulating an allergic response after local tissue exposure. Results: cell-coated filter paper in contact with test material showed the appearance of intracellular blue dye at the same staining density as in control samples, leading to a 0 toxicity rating. Guinea pigs showed no obvious erythema or edema from the irritation test, such that the assessment of colored zirconia ceramic skin allergy response in guinea pig was 0%. Conclusion: this colored zirconia ceramic showed low cytotoxicity and elicited no allergic skin inflammation response, indicating good overall biological safety under these conditions.
Huai-Xiu LU Bin Deng Long-quan Shao Yuan-Fu Yi Jie Liu Wei-Wei Chang Ning Wen
Department of Stomatology, Navy General Hospital, Beijing 100048, China Department of Stomatology, Chinese PLA General Hospital, Beijing 100853,China Department of Stomatology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
国际会议
长沙
英文
509-512
2011-06-30（万方平台首次上网日期，不代表论文的发表时间）