Minocycline Modification of Gelatin-Hydroxylapatite Composite by Co-precipitation Method
Minocycline, a semi-synthetic tetracycline antibiotic, was incorporated into gelatin-hydroxyapatite (HA) composite by using a biomimetic co-precipitation method, Firstly, a certain amount of acidic solution of hydroxyapatite was added into gelatin solution dropwise. After that, different amounts of minocycline (0mg, 50mg, 100mg, 200mg, 300mg) solution was added into the reaction system respectively , and obtain the hydroxyapatite -gelatin-minocycline composite. The results showed that the amount of the minocycline impacted the structure of the composite, and minocycline affects HA crystal growth by maybe bonding to 300 face. The approach described here may provide a basis for the preparation of an antibacterial biomaterial for bone regeneration.
Xiaopeng Zhu Tianyun Ning Xiaohua Xu Wei Liu Quanli Li
Key Lab.of Oral Disease Research of Anhui Province, Stomatologic Hospital & Collage, Anhui Medical U College of Stomatology, Nanjing Medical University, Nanjing 210029, China
国际会议
长沙
英文
513-516
2011-06-30（万方平台首次上网日期，不代表论文的发表时间）